
Ella Taghavi, Technical Sales Engineer at HRS Heat Exchangers.
HRS Heat Exchangers have helped a leading Australian pharmaceutical company expand its production capacity by supplying a bespoke system that controls the temperature of solution materials used in capsule manufacturing.
Mayne Pharma commercializes branded and generic pharmaceuticals in several product areas. Its manufacturing facility is in Salisbury, South Australia, approximately 12 miles from Adelaide, where it produces tablets, capsules, liquids, and creams.
Capsules are a popular method of drug delivery, made of a two-piece dissolvable outer shell containing miniature pellets which carry the active ingredients. The pellets are prepared using a fluid bed dryer to reduce moisture content and are sometimes spray-coated with a solution containing key ingredients. The spray-coating solutions use an alcohol-based formulation to ensure correct mixing and maintenance of the fundamental chemical properties. The solutions must be prepared and applied within a tight temperature range.
Mayne Pharma wanted to expand and upgrade its existing production capacity for capsule production by adding a third fluid bed dryer and the associated equipment while also improving temperature regulation to its existing lines. HRS Heat Exchangers was asked to provide a quotation for a hot water heater to support the new line but quickly realized that a turnkey package offering active heating or cooling as required would provide a much better solution.

The HRS unit uses two K Series multi-pass corrugated tube heat exchangers to maintain solvent temperature as required.
“The alcohol for the solutions is drawn from our outside tank farm,” a spokesperson for Mayne Pharma explained. “One of the issues with the old systems was that on hot days the factory had to wait for the alcohol to cool down before mixing the solutions, which could sometimes take hours. The HRS solution means that we can actively cool it if we need to. Alternatively, if we bring in the alcohol on a cold day, we can heat it up, as necessary.”
The solution produced by HRS is a heater/cooler with the ability to reduce hours of cooling time to less than 60 minutes. Due to space constraints in the existing factory and the requirement to connect various pieces of equipment, the unit was supplied on a compact skid with integrated controls and automation of both heating and cooling processes. Other challenges faced by HRS Engineers were uncertainties about heat transfer in the existing tanks and having to overcome unknown pressure losses in a small jacket annulus which would otherwise affect the performance of the unit.
The HRS unit uses two K Series multi-pass corrugated tube heat exchangers to maintain solvent temperature at 77 °F or 68 °F as required. The hot water loop is composed of one heat exchanger, a centrifugal pump, safety features, and the necessary ancillaries such as a pressure gauge, temperature transmitter, and manual valves.
“The service water is recirculated in a closed loop with the selected solution tank to heat the solvent from 59 °F to the target temperature,” said Ella Taghavi, Technical Sales Engineer at HRS Heat Exchangers. “The process is controlled by temperature transmitters and an autonomous control system, and given the importance of the temperature in the process, product temperature is also monitored via a secondary control loop with transmitters located on each solution tank.”

The line produces pharmaceutical pellets containing the active ingredients in capsules.
Moreover, the cooling section is designed to maintain the product temperature at the targeted set point. Incoming service water from a buffer tank is cooled using chilled water at 42-50 °F from elsewhere in the factory using several passes through the second heat exchanger. “The tank jacket service water is recirculated in a closed loop with the selected solution tank to cool the solvent from 104 °F to the target set temperature of 77 °F or 86 °F,” said Ella. Again, temperature transmitters control the process via an autonomous control loop.
Despite the Covid-19 pandemic, the process of manufacturing, installing, and commissioning the unit ran smoothly, taking less than six months from the order being received to the unit being fully operational. “Covid-19 meant that we weren’t able to undertake Factory Acceptance Testing (FAT) at HRS’s manufacturing facility in Spain, but as it was such a straightforward job, we wouldn’t have insisted on this anyway,” said the spokesperson. “We undertook the commissioning on site with remote support from HRS’s Engineer Ella Taghavi in Melbourne, but apart from a couple of phone calls, nothing else was required.”
HRS
www.hrs-heatexchangers.com
Filed Under: PROCESS PRODUCTS